Serena Celia Humphrey (née van der Woodsen) is a main character in the Gossip Girl series of novels and its television adaption, in which she is portrayed by Blake Lively Serena is considered the "It Girl" of the Upper East Side. Throughout the series, Serena has an on-again, off-again relationship with Dan Humphrey and the two have the longest running relationship on the show; spanning from Pilot to their marriage in the season six finale, New York, I Love You XOXO. She is best friends with Bla
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