The increasing number of reproductive-age women taking antidepressants has raised concerns about the potential risks of using these medications during pregnancy. Literature accumulated over the last decade supports the use of certain selective serotonin reuptake inhibitors (SSRIs) and the older tricyclic antidepressants during pregnancy, indicating no increased risk of congenital malformation in children exposed to these medications during the first trimester of pregnancy. Still, questions remain regarding the purported risk for "toxicity" in newborns exposed to antidepressants around the time of labor and delivery. These concerns are not new. Twenty years ago, case reports suggested that maternal use of tricyclic antidepressants near the time of delivery was associated with problems in the newborn such as difficulty feeding, restlessness, or jitteriness.
Knowns and unknowns about SSRI use during pregnancy in 2022
Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database, Psychological Medicine
Prenatal Antidepressant Use and Risk of Adverse Neonatal Outcomes, Pediatrics
Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database, Psychological Medicine
Frontiers Neonatal Outcomes in Maternal Depression in Relation
Risk of Neonatal Morbidity in Infants Exposed to SSRIs - MGH Center for Women's Mental Health
Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn
Pregnancy and SSRIs: Is There a Risk to the Newborn? - MGH Center for Women's Mental Health
Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors
Table 2 from Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants.
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