Background Although preventable and curable, tuberculosis (TB) still occurs in poor or developing countries, mainly in metropolitan regions of larger cities. The disease is a serious public health problem, and is directly linked to social issues. We analyzed temporal trend variations in areas at risk for concomitant TB, and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the region of Brazil. Methods This ecological study was performed in the municipality of Manaus, in northern Brazil. The population comprised cases with concomitant pulmonary and extrapulmonary TB, registered on the Notifiable Diseases Information System (SINAN), between January 1, 2009 and December 31, 2018. For risk cluster detection, spatial and spatiotemporal scanning statistical techniques were used. The Spatial Variation in Temporal Trends (SVTT) approach was used to detect and infer clusters for significantly different time trends. Results Between 2009 and 2018, 873 concomitant TB cases were registered in Manaus. By using purely spatial scanning statistics, we identified two risk clusters. The relative risk (RR) of the clusters was 2.21 (95% confidence interval [CI]: 1.57–2.88; P = 0.0031) and 2.03 (95% CI: 1.58–2.58; P = 0.0029). Using space-time scanning, we identified a risk cluster with an RR of 3.57 (95% CI: 2.84–4.41; P = 0.014), between 2017 and 2018. For SVTT analyses, three clusters with spatial variations were detected in the significant temporal trends: SVTT 1 (P = 0.042), SVTT 2 (P = 0.046) and SVTT 3 (P = 0.036). Conclusions In Brazil, several TB-determining factors such as race/color, gender, low educational level and low income overlap in needy urban areas and communities, demonstrating that it is unlikely to reach the goals, agreed and launched with the END TB Strategy within the deadlines of international agreements, if there is no reduction in existing inequities determinants and risk of illness in the country.
Gabriel Carrasco - Postdoctoral Researcher - UC San Diego
2 Endemic Infectious Diseases Linked to Chronic Diseases: Implications for Developing Countries, The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary
EMERGING INFECTIOUS DISEASES from CDC. V27-N3 by PermaSafe Protective Coatings - Issuu
Risk-prone territories for spreading tuberculosis, temporal trends and their determinants in a high burden city from São Paulo State, Brazil. - Abstract - Europe PMC
Time trend, social vulnerability, and identification of risk areas for tuberculosis in Brazil: An ecological study
PDF) Risk-prone territories for spreading tuberculosis, temporal trends and their determinants in a high burden city from São Paulo State, Brazil
SciELO - Brasil - COMPLETENESS OF NURSES' RECORDS IN THE CARE OF PEOPLE WITH TUBERCULOSIS: A TREND STUDY COMPLETENESS OF NURSES' RECORDS IN THE CARE OF PEOPLE WITH TUBERCULOSIS: A TREND STUDY
ECTMIH2021 Supplement - 2021 - Tropical Medicine & International Health - Wiley Online Library
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