The body has a certain tolerance level to itching. Once you pass a certain threshold level of histamines, your rash and itching will spread out of control.
Histamine Intolerance is it really a thing? - The Nutrition & Eczema Specialist
Neuroimmune Interactions in Acute and Chronic Itch
Frontiers Itch Processing in the Skin
Hand, Body, or Neck Rash: Thyroid Disease and Chronic Hives
Theories about levels of Itching, histamines, and finding relief
Itch: Pathogenesis and treatment - ScienceDirect
Harvard study may have finally solved mystery of what causes persistent itching - and one in THREE Americans have it
Peripheral and Central Mechanisms of Itch - ScienceDirect
Pathogenesis of allergic diseases and implications for therapeutic interventions
A neuropeptide code for itch. - Abstract - Europe PMC
Comparison of responses to cowhage, histamine, and capsaicin