Merkel cell carcinoma (MCC) is a relatively rare, polyomavirus associated, primary neuroendocrine carcinoma of the skin which is usually arising from dermal skin layers. However, the origin of MCC in the subcutaneous tissue is debatable. We report a 58-yearold female patient with an oedematous mass on her left groin that was firm in consistency and had no discoloration or other visible abnormality of the overlying skin. On histology and immunohistology the tumour was consistent with the diagnosis of MCC showing a predominant subcutanous growth pattern. Pelvic magnetic resonance tomography revealed a tumour conglomerate reaching from the subcutis of the left groin to the left paraaortal and parailiacal region indicating widespread lymphogenic metastisation. Despite complete medical work-up no other MCC primary could be detected. In conclusion, predominant subcutaneous growth pattern as well as tumour localization in the groin are uncommon features of MCC. MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor.
Merkel cell carcinoma – Recent advances in the biology, diagnostics and treatment - ScienceDirect
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Biology, Free Full-Text
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U. Wieland's research works University of Cologne, Köln (UOC) and other places
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Thilo GAMBICHLER, Head of Department, Prof. Dr. med., Ruhr-Universität Bochum, Bochum, RUB, Department of Dermatology
Panniculitic Merkel Cell Carcinoma: Report of a Case and Literature Review
PDF) Map of thrombogenesis in viral infections and viral-driven tumours
